Personalized medicine for dilated cardiomyopathy

Clinical genetics of dilated cardiomyopathy: on the way to personalized medicine?

In their multicentre and multinational study, Haas and co-authors investigated 639 samples of clinically excellently characterized patients with sporadic dilated cardiomyopathy (DCM) and proven familial DCM from eight different cardiology centres in Europe by targeted next-generation sequencing (NGS). All known coding exons of 84 relevant genes in human DCM were covered using an optimized custo...

[Familial dilated cardiomyopathy in patients transplanted for idiopathic dilated cardiomyopathy].

OBJECTIVE To evaluate the prevalence, clinical features, and pattern of inheritance of familial dilated cardiomyopathy (DCM) in heart transplant patients. PATIENTS AND METHOD Patients with idiopathic DCM who had undergone heart transplantation were invited to participate. Patients with alcohol abuse were excluded. A clinical evaluation, 12-lead ECG, echocardiogram, blood tests, and DNA extrac...

Dilated Cardiomyopathy

Dilated cardiomyopathy.

Dilated Cardiomyopathy

Background. Immunization with cardiac myosin induces experimental autoimmune heart disease in genetically predisposed mice. These mice produce heart-specific autoantibodies, some of which are directed against the cardiac myosin isoform. Methods and Results. We have reported the presence of circulating heart-specific autoantibodies in 26% of patients with idiopathic dilated cardiomyopathy (DCM) ...